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Cleavable linkers are widely utilized in the ADC clinical pipeline, with acid-sensitive linkers like hydrazones and silyl ethers leading the way
10.1016/j.joca.2020.01.007 [DOI] [PubMed] [Google Scholar] Zhang J., Hu W., Ding C., Yao G., Zhao H., Wu S
The question is how confidently those effects translate to humans at the doses being used, through the delivery routes being used, over the time periods being used
Protein kinase C activation upregulates human L-type amino acid transporter 2 function
In turn , consistent laboratory protocols support reliable and reproducible experimental outcomes
