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Patients displaying any signs and symptoms suggestive of PML should be immediately referred to a neurology team and vedolizumab should be withheld[86]

666 Consequently, clinical trials are exploring the combination of small-molecule inhibitors targeting epigenetic modulators with targeted therapies as a promising strategy to surmount resistance to targeted treatments

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This polarization of macrophages toward the M1 phenotype in the tumor microenvironment amplifies inflammation and contributes to CRA by promoting iron sequestration and reducing hemoglobin levels