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For instance, metformin, a drug used to treat hyperglycemia, triggers AMPK activation through the AMPK-PGC1 pathway in human umbilical vein endothelial cells (HUVECs), leading to reduced mitochondrial ROS levels, the induction of SOD2, and the enhancement of mitochondrial biogenesis, effectively countering hyperglycemia-induced oxidative stress [153]

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References 1.Barnes H., Goh N.S.L., Leong T.L., Hoy R
