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Twin studies revealed that FA had high heritability, and GWAS and candidate gene studies indicated marked associations of the human leukocyte antigen(HLA)-DR and HLA-DQ region with genetic variants in multiple genes, including Filaggrin (FLG), the HLA locus, and Forkhead Box Protein P3 (FOXP3)
Cyclophilin A was revealed as a candidate marker for human oral submucous fibrosis by proteomic analysis

The immunological anatomy of the skin
It acts as a key building block for glutathione
