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Apart from clinical efficacy defined as the change in Hamilton Depression Rating Scale (HAMD)-17 score, secondary outcomes include changes in pathophysiological mechanisms related to depression as well as changes in local brain activity (functional Magnetic Resonance Imaging, fMRI) and white matter integrity (Diffusion Tensor Imaging, DTI)

Novi AM

Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents

Whether a specific transporter exists for glutathione import into the ER requires further investigation, but it is clear that the selective transport of GSH would provide one possible mechanism for the regulation of the [GSH]:[GSSG] ratio in the ER lumen