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Therefore, to trigger drug release at the cancerous tissue, a DDS can be manipulated to respond to an external stimulus (including heat, ultrasound, light, magnetic field) or an endogenous stimulus (including redox potential, pH, and unique enzymatic activity) in the TME 13,14,15,16

doi: 10.1016/j.neurobiolaging.2019.09.004 184 SunYZhangHLiuRHuangRZhangXZhouSet al

This property may increase the permeability and absorption of a co-administered drug when given orally

Selenium and selenoproteins: Its role in regulation of inflammation