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The authors treated rodents with a VEGF receptor inhibitor which resulted in EC apoptosis and emphysema

Taliou and co-workers performed a pilot study including 50 children diagnosed with ASD [98]

In this final step, glutamine synthetase first reacts with gamma-glutamyl-cysteine to form an electrophilic acylphosphate intermediate by transfer of the gamma-phosphate of ATP to gamma-glutamylcysteine, and then the amino group of glycine acts as a nucleophile to attack the acylphosphate intermediate to form glutathione (28

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This metabolite can accumulate to high levels when -ECS is overexpressed alone, either in the cytosol or the chloroplast (Noctor et al., 1996, 1998a