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Breum L, Astrup A, Gram L, Andersen T, Stokholm KH, Chris-tensen NJ, Werdelin L, Madsen J: Metabolic changes during treatment with valproate in humans: implication for untoward weight gain

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On the other hand, they very rarely flip-flop across the bilayer, as it would require the polar head group to pass into the nonpolar center of the membrane
