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Ceramide is synthesized de novo in the cytoplasmic leaflet of the ER and metabolized to glucosylceramide (GlcCer), a precursor of more-complicated glycosphingolipids 3

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205,206 Used in the farming industry for decades, moenomycin acts as a mimic of the growing glycan chain to enter and compete for the donor site (Figure 11b), with very few known instances of resistance to date

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