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Second, engineering of the TCR domain of IMC-M113V to picomolar affinity was a crucial step towards ensuring it had the capacity to eliminate HIV-infected cells presenting viral peptides at very low levels ( 4-fold increase in serum IL-6 was informed by observations with tebentafusp in patients with metastatic uveal melanoma that showed a strong association with overall survival, suggesting that it could serve as a surrogate for a durably effective immune response 39,41

Chen J, Zhou T, Guo AM, Chen WB, Lin D, Liu ZY, Fei EK

doi: 10.1016/j.semcancer.2019.08.019 134 HuZZhaoYLiLJiangJLiWMangYet al

Free Radic Biol Med (2017) 106:288301

Another study found that, with the exception of soy, the median age of achieving tolerance to inciting foods was 2428 months [26]