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Cycling with breaks of 2-4 weeks between protocols may help maintain response
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However, rates of deaths involving other opioids, specifically heroin and synthetic opioids other than methadone (likely driven primarily by illicitly manufactured fentanyl) (2,3), increased sharply overall and across many states." Rudd RA, Seth P, David F, Scholl L

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doi: 10.1016/j.devcel.2018.07.005 119 MarquesS.ZeiselA.CodeluppiS.van BruggenD.Mendanha FalcoA.XiaoL.et al