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However, their rate is two times lower compared with -carotene and they are not effective in capturing OH and alkoxy radicals (RO ) in vivo (Kohen and Nyska, 2002
doi: 10.1074/jbc.M109.038604 148 Sanz-EzquerroJJCuendaA
This localization theoretically reduces systemic side effects and cancer concerns compared to long-acting analogs, though local effects may still influence surrounding tissues
The researchers found that NiO NPs activated the p38 MAPK pathway and downregulated MEG3 both in vivo and in vitro
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