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A meta-analysis of four clinical trials showed vitamin B12 can be an effective supplement for shingles in treating neuropathic pain and may reduce the need for analgesics

doi: 10.1007/s11060-012-0978-1 102 Penco-CampilloMComoglioYFeliz MorelJHannaRDurivaultJLeloireMet al

[Google Scholar] 198.Uabundit N., Wattanathorn J., Mucimapura S., Ingkaninan K

The clinical evidence exists but is limited small trials, older studies, no large RCTs

Researchers hypothesize that the elevated NAD+ levels increase futile cycling a process where cells burn energy to maintain electrochemical gradients rather than storing it as lipid droplets
