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Researchers observed that Puenarin treatment alleviated the crypt deformation, inflammatory cell infiltration and reduced the pro-inflammatory cytokine markers in the colon mucosa of mice and well act as a potent therapeutic agent that could be used in UC for maintaining gut microbiota homeostasis [131]

N Engl J Med 379(22):20972107

Options include: Fortified foods : Nutritional yeast, plant-based milk alternatives, breakfast cereals, and meat substitutes fortified with B12 (check labels for content) Supplements : Daily supplements of 10 mcg or weekly doses of 2,000 mcg ensure adequate intake, as recommended by the British Dietetic Association The body absorbs approximately 50% of a 12 mcg dose but only about 1% of a 1,000 mcg dose through passive diffusion

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300400 mg/day), highlighting their roles in modulating oxidative and inflammatory pathways, as well as A and tau pathology