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This inflammation can also occur in the central nervous system [58]

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These immune stimulatory factors function as damage-associated molecular patterns, which can transcriptionally activate pro-inflammatory cytokines (TNF-, IL-1, IL-6 and IL-10) and chemokines (MCP-1, MIP-2 and IL-8) [25], [51], [68]

Porphyrins also have absorbance bands in the green and red spectral regions, and light of those wavelengths penetrates deeper into the layers of the gastric mucosa

Importantly, FIH studies also provide essential information for the design of Phase 2 trials , including decisions related to dosing schedules, administration frequency and safety monitoring strategies