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Aerobic exercise has also been shown to significantly enhance analgesia and increase overall functionality in patients with fibromyalgia, primarily by enhancing the endogenous opioid pathways [262]

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Consequently, this phenomenon could explain the detection of the nuclear protein HMGB1, a prototypical damage-associated molecular pattern (DAMP) molecule with a proinflammatory function released by both ferroptotic cells and astrocytes, which triggers different immune responses 40

has served as a speaker or consultant for Biogen, EMD Serono, Novartis, Roche and Sanofi-Aventis