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The multifaceted pyruvate metabolism: role of the mitochondrial pyruvate carrier

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Consistent with this overall concept is the finding that in yeast, the FMN-dependent quinone reductase Lot6 has been shown to act as a redox switch which senses oxidative stress and modulates the binding of the transcription factor Yap4 to the 20s proteasome (Sollner et al., 2009)

In coupled mitochondria, the maximum rate of ETC, measured as oxygen consumption, is only observed in the presence of ADP (Fig

These results indicate that senescence and premature splenic clearance and destruction, rather than direct hemolysis, are the most likely mechanism for the decreased circulating half-life and anemia associated with interrupted glycolysis in erythrocytes in vivo