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Description
Two MT subtypes (MT1 and MT2) have been described, differing in affinity and location
It is primary target is Neutrophil Elastase (NE) (4), a serine protease released by activated neutrophils during inflammation
Mechanisms of alkaliptosis
It has been recently reported that intracellular ROS pathway are widely involved in tumor cell pyroptosis by activating caspases to cut gasdermin family [24, 25]
Produced in the intestinal lumen via dietary fiber fermentation, SCFAs entered systemic and lymphatic circulation and reached the lungs, where they modulated airway inflammation and immune balance
