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In GRXC2, disulfide formation within the CPYC motif revealed a similar midpoint redox potential between 220 and 230 mV upon DTT/dithiane treatment, while HsGRX1 was barely oxidized by dithiane (Supplementary Fig

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Studies suggest this dual approach produces a 3-5 fold increase in growth hormone release compared to either peptide alone, while maintaining natural pulsatile secretion patterns

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