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In addition, the permeability of the LSEC fenestra is heighten, and the nitric oxide secretion makes hepatocytes sensitive to HGF (Poisson et al., 2017)
Document dosing rationales (route, concentration, frequency) and use pilot results to set dose escalation or fixeddose arms in the main study

Nanomaterials (2025) 15(6):436

Probiotics, Prebiotics and Epithelial Tight Junctions: A Promising Approach to Modulate Intestinal Barrier Function

10.2174/1570159x15666170102145257 Curr