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Neuropathobiology of senile dementia and mechanism of action of nootropic drugs

First described back in the 1950s, acne erupts in about one in ten people within days or even hours of getting an injection of vitamin B12, which then disappears rapidly when injection treatment is discontinued. At the time, we had no idea what the mechanism might be, and the problem remained unsolved until just a few years ago when we finally figured it out: Vitamin B12 modulates the gene expression of the skin bacteria that cause acne

doi: 10.1038/s41591-023-02789-4

The absence of observed harm in rodent studies does not confirm a favorable therapeutic index in humans

The peptide also attracts immune cells to wound sites, stimulates nerve growth, and promotes angiogenesis