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David Shusterman told The Post
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People with a higher starting body mass index (BMI) tend to see faster early results because they have more stored fat available for the body to convert into energy

10.1016/j.cub.2008.07.070 Curr

Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis

A Herxheimer reaction may occur during treatment, but more severe symptoms are not necessarily better