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Astrocytes may secrete ferritin through Transient Receptor Potential Mucolipin 1 (TRPML1) - mediated exocytosis (Yu et al., 2023)

[DOI] [PubMed] [Google Scholar] 71.de Heer J, Rasmussen C, Coy DH, et al

SC, PX, JDW, JM, DAW, YW, YZ, NSC, and BZ analyzed and interpreted data (e.g., statistical analysis, biostatistics, computational analysis)

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Using both in vitro (hemin-induced ferroptosis in cultured neurons) and in vivo (collagenase-induced intracerebral hemorrhage in mice) models, the researchers illustrated that NAC effectively prevented hemin-induced ferroptotic cell death in cultured neurons and, when administered post-injury in mice, significantly reduced neuronal loss while enhancing functional recovery