glutathione transferase pathway phenol Simplified scheme of action of the enzymes S-transferases PharmGKB summary: Pathways of acetaminophen

Protein Folding and Aggregation Into Amyloid: The Interference by Natural Phenolic Compounds. International Journal of Molecular Sciences 14: 1241112457

[DOI] [PubMed] [Google Scholar] 150.Vinceti M., Solovyev N., Mandrioli J., Crespi C.M., Bonvicini F., Arcolin E., Georgoulopoulou E., Michalke B

Hepatic Detoxification via Glutathione-S-Transferases In hepatocytesthe primary site of xenobiotic metabolismglutathione (GSH) conjugates electrophilic toxins via glutathione-S-transferases (GSTs), enhancing their solubility to facilitate elimination through bile or urine (26)

Blood 112(11):844, 2008

On the other hand, the DNA in NETs is associated with coagulation, providing a scaffold for platelet binding and stimulating platelet aggregation, activating the extrinsic coagulation pathway, promoting microthrombus formation and leading to pulmonary microcirculation disorders and ventilation/perfusion mismatch, thereby exacerbating lung injury (18)