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Besides diabetes and high blood pressure, the following additional health conditions may also contribute to CKD 1 : Cardiovascular disease Systemic or kidney infections Immune system conditions (eg, lupus) Inflammation of the glomeruli (tiny filters) in the kidneys Inherited kidney disease (eg, polycystic kidney disease) Congenital defects (eg, kidney malformation, urinary tract obstruction) Medications and toxins (eg, prolonged medication, chemical, or street drug exposure) Factors such as those described above and various others can contribute to the decline in kidney function characteristic of CKD

10.1021/acsnano.3c08993 14 ChouV.PearseR

GLP-1 and GIP receptor agonists such as tirzepatide (Zepbound and Mounjaro) can also be used for weight loss and type 2 diabetes management