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Spinal CCL2 and microglial activation are involved in paclitaxel-evoked cold hyperalgesia

With age the animals developed type 2 diabetes, underlining the metabolic consequences of largely elevated GH combined with circulating IGF-I deficiency (34)

Sciannameo et al., 2019

Regular physical activity increases neurotrophic factors such as brain-derived neurotrophic factor (BDNF), enhances cerebrovascular function, and promotes synaptic plasticity through activity-dependent mechanisms (Laitman and John, 2015)

Finally, with advances in synthetic biology and biochemical techniques, molecular therapies focused on protein and gene level regulation are becoming the norm in cancer therapeutic research, and GBM is no exception