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In addition to mediating hyperglycemia-i nduced abnormalities of blood flow and permeability, activation of PKC may contribute to the accumulation of microvascular matrix protein by inducing expression of TNF-1, fibronectin and type IV collagen in both cultured mesangial cells [106,107] and in glomeruli of diabetic rats [97]

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.,MohiteP,PuriA,MundeS,AdeN,BudarA,SinghAKChittasuphoCBioactive compound-fortified nanomedicine in the modulation of reactive oxygen species and enhancement of the wound healing process: A Review.2025;17(7):855 60