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8.1.4 Research limitations and considerations While the evidence is compelling, several limitations must be acknowledged, including the reliance on observational studies for human data, potential confounding factors in epidemiological investigations, and the extrapolation challenges from animal models to human populations

The 10 to the negative ninth molar concentration that showed optimal effects in laboratory settings translates to approximately 0.35 micrograms per milliliter

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10.1007/s00281-018-0701-1 164