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Considering the crucial pathological role of the TGF-/Smad pathway, the therapeutic potential of various natural products in IPF treatment has been explored and reported

Signal Transduction Targeting Ther (2021) 61(6):113

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The loss of topoisomerase II or its inhibition by fluoroquinolones results in accumulation of positively supercoiled mtDNA, followed by cessation of mitochondrial transcription and replication initiation, causing depletion of mtDNA copy number

Cancer Epidemiol Biomarkers Prev 19(6):1484-91, 2010
