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Stressors may disrupt key regulatory molecules in the HF cycle, such as fibroblast growth factor (FGF) and transforming growth factor- (TGF-), promoting a shift from anagen to catagen [54]
Abstract The purpose of this study was to investigate the utility of plasma pharmacokinetic and pharmacodynamic measures including plasma deoxynucleosides, homocysteine and methylmalonic acid concentrations in understanding the time course and extent of the inhibition of thymidylate synthase (TS) by pemetrexed in the context of a phase I/II combination study with vinorelbine
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