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This was clearly demonstrated by a study in which primary cortical neurons treated with subtoxic levels of the GSH-depleting agent, buthionine sulfoximine (BSO), underwent apoptosis in the presence of trace amounts of extracellular copper [17]
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doi: 10.1523/JNEUROSCI.18-07-02570.1998 156 SundbergMSavolaSHienolaAKorhonenLLindholmD
