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A recent cost-benefit analysis with at least 5-year follow-up estimated the direct plus indirect costs of ACI to be $16,781, nearly 20% less than that of TKA ($20,568)
doi: 10.55563/clinexprheumatol/j7ema8 172 RenHLiuLXiaoYShiYZengZDingYet al
757 The similarity in energy metabolism demands between tumor and immune cells results in competition for essential energy substrates

Target concentration An estimate of a drugs volume of distribution and the con- centration range that is associated with the desired clinical response can be used to calculate the loading dose that would achieve the target concentration in a particular patient

Advanced therapy medicinal products: regulation and licensing in UK GOV.UK [Internet]