glutathione peroxidase deficiency 4: a new player in neurodegeneration? Impact of carbonylation on glutathione

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, Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis, Elsevier BV, Jul

Annu Rev Pathol Mech Dis (2017) 12:10330

doi: 10.3390/antiox11030477 101 WangJWangTDingWWuJWuGWangYet al

While the immediate consequence of amplification of mitochondrial oxidant stress is loss of mitochondrial protein function due to modification of thiols [33], peroxynitrite mediated nitrotyrosine formation [48] and oxidative mitochondrial DNA damage [41], the critical event resulting in escalation of cell wide damage is induction of the mitochondrial permeability transition (MPT)