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We observed retardation of growth only when intracellular levels of 5-OP were increased 12-20 fold over the normal levels
Gene expression modulation studies (over 4,000 human genes documented)
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Here, the authors show that the non-neuroendocrine (non-NE) subtype of SCLC is sensitive to ferroptosis while the neuroendocrine (NE) subtype is vulnerable to TRX anti-oxidant pathway inhibition, and the combination of these two treatments in SCLC circumvents non-NE/NE subtype plasticity.
