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Methodological aspects, such as differences in sleep deprivation protocols, brain regions analyzed, and experimental models, along with the observation that the brain does not appear to be significantly damaged by oxidative stress after sleep deprivation, have led to search for signs of oxidative stress in other organs

Based on the data available in 2015, EFSA did not identify any known health risks associated with the use of dietary supplements, so no maximum dose or maximum daily intake, also known as a tolerable upper intake, was set (EFSA, 2015)

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Trends Pharmacol Sci 11: 290296

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