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As key mediators of intercellular communication, EVs can deliver bioactive molecules such as nucleic acids, proteins, and lipids to recipient cells, thereby regulating cell metabolism, microenvironment homeostasis, and physiological functions (Gao et al., 2018)

Excitatory amino acid transporters can reduce synaptic concentration of glutamate, therefore diminishing neurotoxic effect in neurons

Hyperglycemia results in an increased reactive oxygen species (ROS) generated from mononuclear cells [13]

Studies also show a 32% adverse event rate, including liver dysfunction

Methylation is a fundamental biochemical mechanism that plays a critical role in modulating gene expression during neuroinflammation and neurodegenerative disorders 43,44,45