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There is a reason for that

Deprived of blood supply, the fat cells experience ischemic injury

In monotherapy trials with semaglutide oral tablets for T2DM, severe hypoglycemia (requiring the assistance of another person) was reported in 1% of patients receiving the 7 mg tablets and 0% of patients receiving the 14 mg tablets or placebo

It can also cause several GI side effects, which may indirectly affect weight loss 9

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