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Pairing MOTS-c with Lifestyle for Maximum Benefit MOTS-c works best when combined with healthy lifestyle practices: Balanced diet: Adequate protein and micronutrients enhance peptide function

The supplements are in pill form, and the pills have to be taken with a meal

Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )

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Key gaps to address: dose-response in humans, safety/tolerability profiles across populations, interaction effects in stacks, and long-term cardiometabolic outcomes