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Allow 8 to 12 weeks for visible firming, and 4 to 6 months for the full structural response

[DOI] [PMC free article] [PubMed] [Google Scholar] 225.Desideri G, Gentile R, Antonosante A, et al

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145,146 Their responses facilitate maintenance of tissue integrity and repair, but when they trigger feed-forward circuits involving TGF- in response to chronic inflammation, fibroblasts become major contributors to pathologic tissue scarring and organ failure