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Mechanistically, Nerandomilast alleviates the chronic inflammatory milieu of lung tissue by blocking PI3K/Akt/NF-B signaling and down-regulating pro-inflammatory mediators (e.g., IL-1, TNF-), thereby indirectly curbing inflammation-driven EMT activation ( Galunisertib is a highly selective inhibitor of transforming growth factor- receptor I (ALK5) that specifically targets the TGF-/Smad signaling cascade

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IRP1 and IRP2 are cytosolic proteins that bind to IRE in the mRNA of different target genes and control their translation, including TfR1, DMT1, ferritin, and FPN1 [79]

That promotes sperm maturation and enhances the sperm's fertilizing ability