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As in other hemolytic anemias, patients with PKD can develop lowerextremity ulcers, usually medial in association with the medial malleolus, 29 which can be slow to heal or even fail to heal (Figure 2)

MJ: Writing review and editing, Funding acquisition, Supervision, Conceptualization

Vaccaro A.R.., Rizzolo, S.J., Allardyce, T.J., Ramsey, M., Salvo, J., Balderston, R.A., Cotler, J.M.: Placement of Pedicle Screws in the Thoracic Spine: Part I: Morphometric Analysis of the Thoracic Vertebrae

Sem Cell Dev Biol 80:312

This mechanism reveals circATP2B4 as a potential therapeutic target, as its inhibition could disrupt M2 polarization and hinder EOC metastasis ( Figure 5 ) (125)