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This date is determined based on stability studies, compounding conditions, and regulatory guidelines

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Patients with T1DM (who are therefore also taking insulin) who consider switching to the ketogenic diet should exercise particular caution [19]

Many of the technical problems have been solved (see the reviews cited below), and mass spectrometric methods are suited to routine screening of large numbers of samples of biological fluids from neonates, as they permit a considerable degree of automation, both of the analytical steps and of the gathering and interpretation of data, although there appears to be a need for a standardized methodology

S., Ho, J-Y., Thomas, G