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Kiecolt-Glaser JK, Wilson SJ, Bailey ML, Andridge R, Peng J, Jaremka LM, Fagundes CP, Malarkey WB, Laskowski B, Belury MA

Reassessing plant glyoxalases: Large family and expanding functions

This intermediate reacts with molecular oxygen, forming the ferrous verdoheme-HO complex and producing carbon monoxide (CO)

These data support the possibility of local-delivery applications (e.g., topical, inhalation, or GI mucosal targeting) where the short-lived reactive parent compound can act at the site of infection without requiring prolonged systemic exposure (Oluwabusola et al., 2022