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Effects of Tesamorelin (TH9507), a growth hormone-releasing factor analog, in human immunodeficiency virus-infected patients with excess abdominal fat: a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials with safety extension data

Phase 2: Days 16-30 (2 mg/day) From day 16 onward, the dose doubles to 8 units (2 mg per injection)

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Institutional protocols often start at 50mg daily for two weeks, then escalate to 75100mg based on tolerance and objective metabolic markers like NAD+ levels and urinary methylnicotinamide excretion