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The constrained oxygenation and nutrient availability in organoid cultures recapitulate the physiological microenvironment of native tissues [69]
Shock 44, 3643
Han M, Zhang Z, Li X, Tong H, Xu Z, Ding Z, et al
Nat Rev Gastroenterol Hepatol (2017) 14:385385
230 It has also been hypothesized that +1 frameshifted UBBthrough impaired function of the UPSmay contribute to impaired clearance of aggregating tau oligomers and impair the general contributions of the UPS to proteostasis in neurons
