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The study had, as its primary endpoint, changes in Unified Parkinsons Diseases Rating Scale (UPDRS), but despite that serum levels of CoQ 10 were increased in all patients in a way similar to the administration of 1200 mg/day performed by Shults et al., in 2002, no significant changes in UPDRS were observed, suggesting that in a mid-stage of PD, the CoQ 10 supplementation does not induce symptomatic effects [77]

Histopathological and experimental findings suggest that structural gonadal alterations and epigenetic changes may contribute to prolonged fertility impairment

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[DOI] [PubMed] [Google Scholar] 314.Das A.K., Uhler M.D., Hajra A.K