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Mar 2011;34(3):610-615

Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence
A candidate for a potential glutathione-scaffold residue was identified using the following selection criteria: The residue should be rather conserved in enzymatically active in contrast to inactive glutaredoxins and have a charged side chain to ensure a strong ionic glutathione interaction (Fig

Since glutathione is naturally present within all types of cells, it is in a prime position to do this
Gene expression and regulatory activity