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With the advancement of multi-omics sequencing technologies, including proteomics, transcriptomics, and metabolomics, alongside genetic code extension and machine learning, the mapping of lactylation networks, including lactylated proteins, specific modification sites, and protein function in various physiologies and pathologies, is anticipated to be elucidated more comprehensively

At the same time, restoring intestinal barrier function could potentially serve as a therapeutic approach to mitigate extraintestinal organs injuries