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The methodological quality of the included studies, as assessed through the Jadad and NewcastleOttawa scales, varied from moderate to high, while the GRADE assessment indicated moderate certainty of evidence for serum vitamin B12 increase and low certainty for homocysteine reduction

Start: Begin at 500 mcg once daily to gauge tolerability

After an initial loading phase, some patients maintain with monthly injections

28 Neuromyopathy is a rare complication, and there are reports of rhabdomyolysis in patients taking statins

Self-Administration Instructions for Home Use For those needing regular shots, doing them at home can be easier