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10.1038/mp.2015.182 [DOI] [PMC free article] [PubMed] [Google Scholar] Pietronave S., Forte G., Locarno D., Merlin S., Zamperone A., Nicotra G., et al

Furthermore, the upregulation of HMGB1 was positively correlated with IL-1 [110]

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10.1016/j.freeradbiomed.2018.01.033 135 NapolitanoG.FascioloG.VendittiP

(Peptide Sciences) While senescence is protective in acute contexts (e.g., preventing malignant transformation, wound repair), the accumulation of senescent cells over time is detrimental: They occupy tissue space and resources, impairing progenitor cell function